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โ† Trials
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Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility

Recruitingn/aAges 20 Years - 45 YearsFemaleTang-Du Hospital
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In plain words

What the trial is, and whether it could suit you

The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility. Researchers will utilize an ultrasound multimodal system to systematically assess endometrial parameters, including thickness, morphology, peristalsis, and blood flow indices. The study aims to enroll approximately 300 infertile women aged 20 to 45 years. Participants will be observed and grouped based on whether they receive anticoagulant medications, such as aspirin or heparin sodium, as part of their standard clinical care. The study will track ultrasound-based receptivity indicators and follow up on pregnancy status and outcomes at 45 and 90 days of gestation. This study is purely observational, and all clinical treatment decisions are made independently of the study proto

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 20 to 45 years. Clinically diagnosed with infertility and planning to undergo embryo transfer or monitored conception cycles. Patients who have complete baseline clinical data and are willing to undergo multimodal ultrasound evaluation of endometrial receptivity during the window of implantation. Voluntarily agreed to participate in this observational study and signed the informed consent form for data collection. Exclusion Criteria: * Presence of congenital uterine malformations (e.g., septate uterus, bicornuate uterus, unicornuate uterus) that significantly alter the endometrial cavity. Presence of untreated severe intrauterine lesions, such as submucosal fibroids, severe intrauterine adhesions, or endometrial polyps that may mechanically interfere with implantation. Severe underlying systemic diseases, including but not limited to severe liver or kidney dysfunction, or malignant tumors. Known severe bleeding disorders or strict contraindications to anticoagulant medications (for patients in the routine clinical care setting). Patients who are unable to cooperate with the transvaginal multimodal ultrasound examination or complete the required follow-up for pregnancy outcomes.
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What it tests

  • Routine Anticoagulant Therapy (Aspirin or Heparin Sodium)
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Where

1 site
Tangdu Hospital, Air Force Medical University
Xi'an, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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