🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Corticosteroid Tapering in Sarcoidosis

RecruitingNAAges 18 Years - anyAllRoyal Brompton & Harefield NHS Foundation Trust
NCT07498842 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Sarcoidosis is an inflammatory condition affecting many different parts of the body but most commonly the lungs. It is not known what causes sarcoidosis. In some patients no treatment is needed but in other patients long term treatment may be required. One of the main medications used to manage this condition is corticosteroids. This medication has been shown to be very effective at reducing inflammation in this condition and many patients often remain on it for months to years. Unfortunately, there are many negative long-term side effects of corticosteroid use. This includes an increased risk of developing diabetes, reduced bone density, weight gain, high blood pressure and low muscle mass. Currently there are no guidelines for how steroids should be weaned in patients who have stable sarcoidosis. The investigators aim to undertake a study at the Royal Brompton Hospital which will be

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Confirmed sarcoidosis by: (a) Histological diagnosis and/or (b) Multidisciplinary Team (MDT) diagnosis * Prednisolone 5-10mg/day for \> 6 months * Clinically stable disease for \> 6 months (no flares or dose escalation) * On or off second-line agent * \> 18 years old * Written informed consent provided Exclusion Criteria: * Cardiac or neurosarcoidosis * Advanced pulmonary sarcoidosis defined as either: (a) composite physiological index (CPI) \> 40 (b) pulmonary hypertension * Active sarcoidosis flare or dose escalation in the past 6 months * Known adrenal insufficiency * Pregnancy or breastfeeding * Previous or current infliximab use
💊

What it tests

  • Standard prednisolone taper
  • Fast prednisolone taper
📍

Where

1 site
Royal Brompton Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy