🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal Detachment

RecruitingNAAges 18 Years - anyAllFondazione G.B. Bietti, IRCCS
NCT07500324 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration, diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center. Biological samples, including peripheral blood, tears, aqueous humor, vitreous humor, and subretinal fluid, will be collected during routine clinical and surgical procedures. Advanced clinical proteomics approaches will be applied to characterize molecular signatures associated with disease onset, progression, and response to treatment. The study seeks to improve the understanding of disease pathophysiology and support the development of novel diagnostic and prognostic biomarkers in ophthalmology.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Ability to understand the study procedures and provide written informed consent * Willingness and ability to comply with study procedures and visits For case subjects: * Patients with age-related macular degeneration (intermediate or advanced, including geographic atrophy or neovascular AMD) * Patients with diabetic retinopathy (non-proliferative or proliferative, with or without diabetic macular edema) * Patients undergoing surgery for primary or recurrent retinal detachment For control subjects: * Patients scheduled for cataract surgery with no documented retinal diseases (e.g., AMD, diabetic retinopathy, retinal vascular occlusions, or retinal epithelial disorders) * Outpatients with no documented retinal diseases * For retinal detachment subgroup: patients undergoing macular surgery (e.g., macular pucker or macular hole) or cataract surgery with attached retina Exclusion Criteria: * Age \< 18 years * Presence of infectious ocular diseases * Alterations in the electrophoretic profile of gamma globulins
💊

What it tests

  • Biological Sample Collection
📍

Where

1 site
IRCCS Fondazione G.B.Bietti
Roma, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy