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Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro

RecruitingNAAges 18 Years - anyAllOswaldo Cruz Foundation
NCT07500415 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil, including men who have sex with men, transgender women, and travestis who are living with HIV or using HIV pre-exposure prophylaxis (PrEP). Bacterial STIs such as syphilis, gonorrhea, and chlamydia remain common in these populations, even with existing prevention strategies. This study aims to answer the following questions: whether doxy-PEP can reduce the number of new STIs, whether it is safe and well tolerated, whether participants use it as recommended, and whether its use may contribute to antibiotic resistance or changes in the body's natural bacteria. Doxy-PEP involves taking a dose of doxycycline, an antibiotic, shortly after sexual activity to reduce the ris

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📋 Eligibility rules (as published)
Inclusion Criteria: * Individuals assigned male at birth (cisgender or transgender men), transgender women, or travestis who have sex with men * Age ≥18 years * Living with HIV or currently using HIV pre-exposure prophylaxis (PrEP) for at least 6 months * History of at least one bacterial sexually transmitted infection (chlamydia, gonorrhea, or syphilis) in the past 12 months (laboratory-confirmed or self-reported) * Willing and able to provide informed consent Exclusion Criteria: * Known allergy or hypersensitivity to doxycycline or other tetracycline-class antibiotics * Current use of medications that may significantly interact with doxycycline or are contraindicated, including systemic retinoids, barbiturates, carbamazepine, or phenytoin
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What it tests

  • Doxycycline
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Where

1 site
Instituto Nacional de Infectologia Evandro Chagas
Rio de Janeiro, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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