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Robotic-Assisted Versus Conventional Bronchoscopy for Cryobiopsy in the Diagnosis of Interstitial Lung Disease

RecruitingNAAges any - anyAllUniversity of Zurich
NCT07500818 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Interstitial lung disease (ILD) often requires histopathological confirmation when high-resolution computed tomography (HRCT) findings are inconclusive. Transbronchial lung cryobiopsy has emerged as a less invasive alternative to surgical lung biopsy, but diagnostic yield remains variable and dependent on biopsy location and procedural precision. Robotic-assisted bronchoscopy (RAB) combined with cone-beam computed tomography (CBCT) may allow more precise navigation to target lung segments and potentially improve biopsy quality and diagnostic yield. This multi-center, investigator-initiated randomized controlled trial will compare conventional bronchoscopy with 2D fluoroscopy guidance versus robotic-assisted bronchoscopy with CBCT guidance for transbronchial lung cryobiopsy in patients undergoing diagnostic evaluation for suspected interstitial lung disease. Participants will be random

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years * Clinical suspicion of interstitial lung disease requiring histological confirmation * Non-diagnostic HRCT pattern (e.g. probable UIP or indeterminate pattern) * Candidate for transbronchial lung cryobiopsy * Ability to provide informed consent Exclusion Criteria: * Definite UIP pattern on HRCT * Severe pulmonary hypertension * Severe hypoxemia contraindicating bronchoscopy * Coagulopathy or contraindication to biopsy * Pregnancy * Inability to provide informed consent
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What it tests

  • Robotic-Assisted Bronchoscopy With Cone-Beam CT Guidance
  • Conventional Bronchoscopy With Fluoroscopy Guidance
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Where

2 sites
Cantonal Hospital of Lucerne
Lucerne, Switzerland
University Hospital Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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