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Hyaluronic Acid in Endodontic Microsurgery

RecruitingNAAges 18 Years - anyAllUniversity of Bern
NCT07501585 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first molars. Participants previously treated with non-surgical endodontic therapy will be allocated to either endodontic microsurgery with cross-linked hyaluronic acid application (test group) or the same surgical procedure without adjunctive material (control group), with 12 months of follow-up. The study hypothesis is that cross-linked hyaluronic acid improves soft- and hard-tissue healing, reduces postoperative inflammation and pain, and supports more stable surgical outcomes. Primary outcomes include early soft tissue healing (Early Wound Healing Score, day 4) and postoperative pain (visual analogue scale). Secondary outcomes include periapical healing assessed by b

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent * ≥18 years of age * Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment * Full mouth plaque score (FMPS) and bleeding score (BoP) \< or 20% * Periapical lesion \< or 10 mm * Four-wall bone defect morphology Exclusion Criteria: * Smokers of more than 10 cigarettes a day * Allergy to hyaluronic acid * Pregnancy or lactation * Uncontrolled Diabetes * Untreated periodontal conditions * Any conditions associated with poor compliance or failure to maintain good oral hygiene * Acute infections lesions in areas intended for surgery * Chemotherapy and radiotherapy treatment
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What it tests

  • Hyaluronic Acid
  • Endodontic microsurgery
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Where

1 site
Praktika 1
Moscow, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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