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Topical 2-Deoxy-D-ribose Hydrogel Versus Minoxidil 5% Solution for Androgenetic Alopecia

RecruitingNAAges 18 Years - 50 YearsAllKasr El Aini Hospital
NCT07502976 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Androgenetic alopecia is a common form of hair loss that can affect quality of life. This randomized controlled trial aims to evaluate the efficacy and safety of topical 2-Deoxy-D-ribose (2dDR) hydrogel compared with topical minoxidil 5% solution in the treatment of mild to moderate androgenetic alopecia in adults aged 18 to 50 years. Sixty participants will be randomized into 2 treatment groups. The 2dDR group will apply 1 gram of topical 2dDR hydrogel once daily to the affected scalp areas for 6 months. The minoxidil group will apply topical minoxidil 5% solution to the affected scalp areas for 6 months according to sex-specific dosing in the protocol. Participants will undergo clinical assessment, trichoscopic evaluation, and standardized scalp photography at baseline, Week 12, and Week 24. The study will also assess tissue vascular endothelial growth factor (VEGF) levels using scalp

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 to 50 years. * Male and female patients with androgenetic alopecia. * Mild to moderate disease severity, defined as Hamilton-Norwood scale II to V in males and Ludwig scale I to II in females. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Other types of hair loss, including inflammatory or scarring alopecia. * Psoriasis. * Inflammatory scalp dermatoses. * History of severe systemic disease, including renal, cardiovascular, or hepatic disease. * Chemotherapy during the last 5 years. * Pregnancy. * Lactation. * Bleeding disorders.
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What it tests

  • Topical 2-Deoxy-D-ribose Hydrogel
  • Topical Minoxidil 5% Solution
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Where

1 site
Kasr El Aini Hospital
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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