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Physiological Study of High PEEP in Noninvasive Ventilation

RecruitingNAAges 18 Years - 100 YearsAllChongqing Medical University
NCT07503509 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years 2. PaCO₂ ≤ 50 mmHg 3. PaO₂/FiO₂ ≤ 300 mmHg 4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) - Exclusion Criteria: 1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included) 2. Pneumothorax 3. Patients who refuse to participate in this trial -
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What it tests

  • high PEEP
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Where

1 site
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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