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Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability

Recruitingn/aAges 18 Years - anyAllZhongda Hospital
NCT07504731 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg) * Under continuous sedation with or without paralysis Exclusion Criteria: * Age \<18 years * Bronchopleural fistula * Pure COPD exacerbation * Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement) * Hemodynamic instability (Systolic BP \< 75 mmHg or MAP \< 60 mmHg despite vasopressors and/or heart rate \< 55 bpm) * Contraindications to mobilization (e.g., intracranial hypertension, spinal cord injury) * Intra-abdominal hypotension (IAP≥12mmHg) * Pregnancy * Attending physician deems the transient application of high airway pressures to be unsafe
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What it tests

  • Specific lung recruitment maneuvers and decremental PEEP steps
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Where

3 sites
Zhongda Hospital, Southeast University
Nanjing, China
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, China
West China Hospital of Sichuan University
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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