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Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing

RecruitingPhase 1, Phase 2Ages 20 Years - 45 YearsAllAl Salam University
NCT07508033 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal. This research compares PRF to a newer treatment using "exosomes" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 20 and 45 years. * Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area. * Presence of adjacent teeth to the extraction site. * Adequate oral hygiene (Plaque Index \< 20%). * Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan. * Signed informed consent provided by the participant. Exclusion Criteria: * Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism). * History of head and neck radiation therapy or bisphosphonate medication use. * Active infection or acute abscess at the extraction site. * Heavy smokers (more than 10 cigarettes per day). * Pregnant or lactating women. * Patients with poor oral hygiene or active periodontal disease in the rest of the mouth. * Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).
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What it tests

  • MSC-Derived Exosomes
  • Platelet-rich fibrin (PRF)
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Where

1 site
Department of Oral & Maxillofacial Surgery, Al Salam University
Tanta, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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