🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Thessaly
NCT07510061 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure. The Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe. Ad

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Study Population Healthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe). Inclusion Criteria * Age 18-65 years (or your protocol-specific age range) * Healthy as determined by medical history screening questionnaire * Able to provide written informed consent * Able to complete heat exposure and light exercise protocol * No heat acclimatization or extensive sun exposure in the previous 4 weeks * Fitzpatrick skin type I-IV (if applicable for UV testing) * Willing to undergo blood sampling, urine collection, and skin biopsy Exclusion Criteria * History of cardiovascular, metabolic, neurological, or dermatological disease * History of heat-related illness (e.g., heat stroke) * Use of medications affecting thermoregulation or cardiovascular function * Smoking or substance abuse * Pregnancy or breastfeeding * Abnormal ECG or uncontrolled hypertension * Recent severe sunburn or UV treatment * Contraindications to skin biopsy * Inability to tolerate heat exposure during screening
💊

What it tests

  • Controlled Heat and Ultraviolet Radiation Exposure Protocol
📍

Where

2 sites
Københavns Universitet
Copenhagen, Denmark
Department of Physical Education and Sport Science
Trikala, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy