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Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in VATS Partial Pneumonectomy

RecruitingPhase 4Ages 18 Years - 65 YearsAllSanming First Hospital
NCT07512635 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Video-assisted thoracoscopic surgery (VATS) is a minimally invasive approach for partial pneumonectomy, but postoperative pain remains a major challenge affecting recovery. Intercostal nerve block (ICNB) with conventional local anesthetics provides limited duration of analgesia, often insufficient to cover the peak pain period after surgery. Liposomal bupivacaine is a long-acting formulation designed to provide extended analgesia up to 72 hours. This study aims to evaluate the effect of preoperative ICNB with liposomal bupivacaine compared with conventional bupivacaine hydrochloride on postoperative quality of recovery in patients undergoing VATS partial pneumonectomy. The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively. We hypothesize that liposomal bupivacaine ICNB results in superior recovery quality compared with conventional bupivacaine, with

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients scheduled for thoracic surgery under general anesthesia via thoracoscopic approach; * Age 18-65 years; * Classified as Grade I-II by the American Society of Anesthesiologists (ASA). Exclusion Criteria: * History of local anesthetic allergy. * Chronic opioid users. * Contraindications for nerve block, including infection at the puncture site and coagulation disorders; * Language communication impairment. * Other conditions unsuitable for inclusion in the trial.
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What it tests

  • Bupivacaine Hydrochloride
  • Bupivacaine liposome
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Where

1 site
SanMing First Hospital
Sanming, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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