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Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy

RecruitingNAAges 18 Years - anyAllFundació Institut de Recerca de l'Hospital de la …
NCT07514650 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the intensive care unit (ICU). The study assesses whether the use of continuous venovenous hemodiafiltration (CVVHDF) with post-filter replacement under citrate anticoagulation reduces electrolyte losses and the need for electrolyte supplementation compared with standard dialytic CRRT. Participants receiving standard CRRT will be compared with those treated with the modified protocol. The duration of participation corresponds to the period during which CRRT is required. Data collection will cease once CRRT is discontinued.

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📋 Eligibility rules (as published)
Inclusion Criteria * Age ≥18 years * Admission to the intensive care unit (ICU) * Diagnosis of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) * Use of regional citrate anticoagulation during CRRT Exclusion Criteria * Known allergy or intolerance to citrate * Contraindications to citrate anticoagulation (e.g., severe liver failure or severe metabolic disorders affecting citrate metabolism) * Pregnancy or breastfeeding
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What it tests

  • continuous renal replacement therapy
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Where

1 site
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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