Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation

Inclusion Criteria: 1. Patients who meet the diagnostic criteria for acute HZ27 and skin symptom appears less than 7 days; 2. Only have lesions in the trunk and limbs; 2\. Patients with a Numerical Rating Scale (NRS) score ≥ 4; 3. Aged between 20 and 80 years; 4. Patients voluntarily participate in the trial and are willing to sign the informed consent. Exclusion Criteria: 1. Special types of HZ that occur in head, eyes, viscera, etc. or those combined with other skin diseases; 2. Has received relevant treatment and it may affect the observation indicators; 3. Pregnant and lactating women; 4. Patients who are allergic to iodophor or other topical disinfectants, or a history of sudden, potentially life-threatening systemic allergic reactions; 5. Those who are afraid of acupuncture or have metal implants and are not suitable for EA treatment; 6. Those with contraindications to pregabalin such as congestive heart disease and heart failure; 7. Patients with severe primary diseases such as liver, kidney, cardiovascular and cerebrovascular, metabolic, autoimmune system diseases, malignant tumors, etc., and those with mental illness; 8. Patients who have hematologic diseases or coagulation disorders; 9. Patients who are currently participating in other clinical studies.