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Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia

RecruitingNAAges 18 Years - 65 YearsAllUniversite du Littoral Cote d'Opale
NCT07516028 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hypoxia, defined as a reduction in the availability of oxygen, induces significant physiological adaptations. While the deleterious effects of severe and chronic hypoxia are well documented, several studies indicate that moderate hypoxia - particularly when administered intermittently - may produce beneficial effects on cardiometabolic health (e.g., improved regulation of blood pressure and better glycaemic control). However, its impact on the dynamics of brain circuits in humans remains relatively underexplored. The present project aims to characterise the effects of continuous and intermittent moderate hypoxia on resting-state brain dynamics in healthy adults. To this end, simultaneous electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings will be conducted in order to extract functional and haemodynamic markers of brain activity. This project will co

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female aged 18 to 65 years * Healthy right- or left-handed individuals with no self-reported neurological disorders or history of neurological conditions (e.g., epilepsy, stroke, brain or spinal surgery, or neurological diseases affecting motor or sensory function such as multiple sclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's) * Individuals who have provided informed consent and have sufficient proficiency in French * Participants affiliated with, or beneficiaries of, a social security scheme Exclusion Criteria: * Body mass index (BMI) greater than 30 kg/m² * Diagnosed and untreated obstructive sleep apnoea syndrome * Inability to provide informed consent * History of cardiac (e.g., ischaemic heart disease, heart failure) and/or respiratory disorders (e.g., COPD, chronic respiratory insufficiency, persistent or uncontrolled asthma) * Current smokers * Contraindications to TMS (e.g., uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp lesions, elevated intracranial pressure, cerebrospinal fluid shunt) * Use of psychotropic medication * Individuals under legal guardianship or curatorship * Pregnant or breastfeeding women * Participants who have flown by air or travelled to terrestrial altitudes above 1500 metres within the seven days prior to inclusion
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What it tests

  • Moderate hypoxia
  • Normoxia
  • Transcranial Magnetic Stimulation
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Where

1 site
Eurasport
Loos, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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