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Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock

Recruitingn/aAges 18 Years - anyAllMenoufia University
NCT07516236 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using echocardiography (VTI) and cardiometry. We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * Diagnosis of septic shock according to Sepsis-3 criteria: Suspected or confirmed infection o Requirement for vasopressors to maintain MAP \> 65 mmHg o Serum lactate \> 2 mmol/L despite adequate fluid resuscitation Exclusion Criteria: * Pregnancy * Significant valvular heart disease. * Atrial fibrillation. * Inadequate echocardiographic window. * Ongoing bleeding or contraindication to fluid bolus.
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What it tests

  • Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
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Where

1 site
Menoufia University
Menouf, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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