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SLIT ABS: Study on Patients With Autoimmune Podocytopathy

RecruitingNAAges 0 Years - 99 YearsAllMeyer Children's Hospital IRCCS
NCT07516964 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nephrotic syndrome is a kidney condition that mainly affects children and is characterized by high levels of protein in the urine, low levels of protein in the blood, and swelling. While many children respond well to steroid treatment, a large proportion experience relapses or become dependent on therapy. In some cases, the disease does not respond to standard treatments and may progress to chronic kidney disease. Recent research suggests that, in addition to genetic factors, immune system mechanisms may play a key role in the development and progression of nephrotic syndrome. In particular, some patients produce autoantibodies against nephrin, an essential protein of the kidney filtration barrier. These autoantibodies may be associated with disease activity and treatment response. The aim of this study is to investigate the presence of anti-nephrin autoantibodies in children with neph

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pediatric and adult patients with a diagnosis of podocytopathy * Patients with nephrotic syndrome and/or histological diagnosis of minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy (CG), or diffuse mesangial sclerosis (DMS) * Both newly diagnosed (incident) patients and patients already under follow-up at participating centers * Availability of clinical data from medical records (including paper and/or electronic records, laboratory reports, and discharge summaries) * Availability of biological samples (e.g., blood and/or renal biopsy), if collected as part of routine clinical care * Signed informed consent by the patient or legal guardian (and assent when applicable) Exclusion Criteria: * Refusal or inability of the patient, parents, or legal guardian to provide informed consent * Lack of sufficient clinical data or unavailable biological samples required for the study
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What it tests

  • Serum and renal tissue analysis
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Where

14 sites
Mayo Clinic
Rochester, United States
Ludwig-Maximilians Universitat
München, Germany
Ospedale Santa Maria Annunziata
Bagno a Ripoli, Italy
Meyer Children's Hospital IRCCS
Florence, Italy
IRCCS Azienda Ospedaliero - Universitaria
Bologna, Italy
Azienda Ospedaliero Universitaria Careggi
Florence, Italy
Ospedale S. Giovanni di Dio
Florence, Italy
IRCCS Istituto Giannina Gaslini
Genova, Italy

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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