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Methadone for Post-operative Spine Surgery

RecruitingPhase 4Ages 18 Years - 120 YearsAllBrandon Knopp
NCT07517679 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes in adult patients undergoing elective spine surgery, with the goal of improving postoperative analgesia and enhancing recovery efficiency. The main questions it aims to answer are the perioperative pain control and opioid requirements between the two groups. Post-induction methadone can offer equivalent or improved pain control following major spine procedures and reduce intra- and postoperative opioid requirements, improve perioperative pain control and shorten PACU stay. Researchers will compare perioperative opioid use (morphine equivalents (ME), during the intraoperative and postoperative periods (PACU and 24-hour totals) between the standard intraoperative opioid regimen group and the methadone group. P

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📋 Eligibility rules (as published)
Inclusion Criteria: * Undergoing elective spine surgery (e.g., fusion, decompression) * Expected postoperative inpatient admission * Able to provide informed consent * Patients with opioid use disorder (OUD) may be included if on stable maintenance therapy Exclusion Criteria: * Use of regional or neuraxial anesthesia * Contraindication to methadone use (e.g., prolonged QTc, allergy, severe hepatic disease) * Cognitive impairment precluding consent or accurate pain scoring
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What it tests

  • Methadone
  • Standard of care
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Where

1 site
University of Kentucky
Lexington, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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