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Protecting Against Lenacapavir Misinformation With Young Women in Gauteng, South Africa ( PROTECT-L)

RecruitingNAAges 18 Years - 29 YearsFemaleUniversity of Pennsylvania
NCT07518914 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Adolescent girls and young women (AGYW) in South Africa remain disproportionately affected by HIV, with prevalence among 15-24-year-olds at 9.4% in 2024 despite expanded access to condoms, HIV testing, and oral PrEP. While oral PrEP is effective, its reliance on daily adherence and regular follow-up has limited impact for many young women. Lenacapavir (LEN), the first long-acting injectable PrEP administered twice yearly, offers a promising alternative that could improve persistence and protection. However, LEN's potential may be undermined by misinformation, particularly around safety and trust, which has been shown in other HIV prevention contexts to reduce uptake and demand. Proactive strategies, such as psychological inoculation, are therefore needed to prebunk misinformation and support future LEN implementation among AGYW. Primary objective: To compare changes in intentions to rec

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female (cisgender or transgender) * Age 18-29 years * Self-reported history of sexual activity in the past 12 months * Self-reported HIV-negative status or unknown HIV status at enrolment * Willing and able to provide consent * Able to read and understand English Exclusion Criteria: Unwilling or unable to provide consent for study participation.
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What it tests

  • Diabetes information
  • Enhanced inoculation message
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Where

1 site
Health Economics and Epidemiology Research Office, University of the Witwatersrand
Johannesburg, South Africa
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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