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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

RecruitingPhase 3Ages 18 Years - anyAllIncyte Corporation
NCT07522073 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate the efficacy and safety of standard chemotherapy with or without INCB161734 in participants with metastatic pancreatic ductal adenocarcinoma (PDAC).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically or cytologically confirmed metastatic PDAC with a KRAS G12D mutation * No prior systemic treatment in the metastatic setting * ECOG Performance status 0-1 * Adequate organ function Exclusion Criteria: * Prior treatment with any KRAS inhibitor * Chronic or current active infection requiring systemic treatment within 1 week prior to the first dose of study drug * Known active CNS metastases Other protocol-defined Inclusion/Exclusion Criteria may apply.
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What it tests

  • INCB161734
  • Placebo
  • Investigator's choice of chemotherapy
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Where

228 sites
Investigative Site US058
Birmingham, United States
Investigative Site US016
Anchorage, United States
Investigative Site US026
Chandler, United States
Investigative Site US045
Tucson, United States
Investigative Site US051
Duarte, United States
Investigative Site US085
Fullerton, United States
Investigative Site US054
La Jolla, United States
Investigative Site US086
Long Beach, United States

…and 220 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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