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Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

RecruitingNAAges 18 Years - anyAllUniversity of Sao Paulo
NCT07522684 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop techniques that favor its control and stability in the short and long term. After non-surgical periodontal therapy (NSPT), the first phase of PE treatment, residual periodontal pockets may persist, often associated with intraosseous defects, which compromise the tooth's prognosis and are associated with disease progression and increased treatment complexity. Surgical treatment of intrabony defects often results in the formation of long junctional epithelium, weakly attached to the root surface, since true regeneration of periodontal tissues is an unpredictable event and depends on complex biological processes. In recent decades, various biomaterials have been pro

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥ 18 years of age; * diagnosis of periodontitis stage III or IV, grade B or C (Chapple et al., 2018; Papapanou et al., 2018); * full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) of ≤ 20%; * presence of a 2- or 3-wall intrabony defect with a depth ≥ 3 mm and probing depth and clinical attachment level ≥ 5 mm in the interproximal region of a single- or multi-rooted tooth; * pulp vitality or satisfactory endodontic treatment in the tooth to be treated; * at least 1 mm of keratinized tissue on the buccal surface of the tooth to be treated. Exclusion Criteria: * presence of furcation involvement associated with the intrabony defect; * presence of systemic conditions that may affect the progression of periodontitis or the response to its treatment; * long-term use of anti-inflammatory or immunosuppressive medications; * use of antimicrobials within the last 6 months; * continuous use of mouthwashes containing antimicrobial agents within the last 6 months; * need for prophylactic antibiotic therapy for routine dental procedures; * current or past tobacco use within the last 5 years; * pregnancy; * breastfeeding.
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What it tests

  • Polynucleotide and hyaluronic acid-based gel
  • Control
  • Xenogeneic bone graft
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Where

1 site
Ribeirão Preto School of Dentistry, University of São Paulo
Ribeirão Preto, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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