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Effect of Meal Timing During Adjuvant Treatment for Cancer

RecruitingNAAges 18 Years - anyAllFred Hutchinson Cancer Center
NCT07524218 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to test meal-timing as a novel and sustainable interventional approach during cancer treatment to improve therapeutic response, patient well-being and long-term metabolic health. In alignment with these priorities, we propose to focus on patients with histologically or cytologically confirmed solid tumors treated with curative-intent surgical resection and planned initiation of systemic adjuvant therapy (chemotherapy, targeted therapy, immunotherapy, and/or radiation per standard of care). A promising strategy for improving the efficacy of anticancer treatments and reducing associated toxicities involves combining treatment with fasting regimens. In pre-clinical and clinical studies, various forms of fasting have been shown to induce tumor regression and improve long-term survival. According to the differential stress sensitization theory, fasting is t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years (no upper age limit) * Any sex or gender * Histologically or cytologically confirmed solid tumor treated with curative-intent surgical resection and planned initiation of systemic adjuvant therapy (chemotherapy, targeted therapy, immunotherapy, and/or radiation per standard of care) * BMI ≥18.5 kg/m2 * Willing and able to adhere to the assessments, visit schedules, prohibitions, and restrictions Exclusion Criteria: * No plan for systemic adjuvant therapy after surgery * Strictly adhering to a \<10-hour eating window on most days * Regular overnight shift work (≥1 night shift per week) * Dependent on parenteral or enteral nutrition * Pregnant or breastfeeding * Active second malignancy requiring systemic therapy (exceptions: non-melanoma skin cancers or in situ cervical cancers adequately treated) * Severe psychiatric, cognitive, or social conditions that would interfere with adherence to study procedures
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What it tests

  • Time-restricted eating
  • Questionnaire Administration
  • Biospecimen Collection
  • Health coaching
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Where

1 site
Cedars Sinai Medical Center (CSMC)
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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