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Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging

RecruitingNAAges 18 Years - anyAllUniversidad Complutense de Madrid
NCT07527351 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is designed to validate laser speckle contrast imaging (LSCI) as a non-invasive method for measuring superficial gingival blood perfusion. Accurate assessment of vascularization is essential for understanding periodontal and peri-implant wound healing, yet current clinical methods are limited by subjective interpretation and low reproducibility. Repeated LSCI measurements will be performed in healthy gingival tissues and in tissues undergoing different mucogingival healing patterns, including primary and secondary intention healing. The study will also evaluate factors that may influence perfusion readings, such as angulation, retractors, mirror use, temperature, and heart rate. The primary objective is to determine the reproducibility of LSCI measurements and to support its use as a reliable tool for monitoring oral soft-tissue vascularization and healing.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 years or older * Non-smokers * Good systemic health * Good periodontal health * No current systemic medication * Good oral hygiene * For the retrospective surgical component: availability of previously documented clinical records from closed mucogingival surgical wounds or open palatal donor-site wounds, with prior consent allowing use of documented clinical material for research Exclusion Criteria: * Pregnancy * Use of anti-inflammatory medication within 7 days before evaluation * Oral treatment within 6 months before evaluation * For the prospective healthy-gingiva component: any condition not compatible with good systemic or periodontal health * For the retrospective surgical component: absence of adequate previously documented clinical records or absence of prior consent for research use of the documented material
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What it tests

  • Laser Speckle Contrast Imaging
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Where

1 site
Complutense University of Madrid
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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