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Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques

RecruitingNAAges 18 Years - 65 YearsAllÖrebro University, Sweden
NCT07527793 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates short-term intra- and inter-individual variability in human blood metabolism under real-life conditions. Using minimally invasive finger-prick blood sampling, dietary records, and wearable devices, we will longitudinally monitor blood-circulating metabolites and glucose levels in healthy individuals over a four-week period without dietary or lifestyle intervention. The study focuses on metabolic transitions between pre- and postprandial states during habitual daily activities and routine meals. Mass spectrometry-based metabolomics will be used to characterize metabolite profiles and their associations with diet, physical activity, sleep, and stress. In parallel, the study evaluates the feasibility of microsampling approaches, wearable-derived physiological data, and isotope-labelled standards for robust and cost-effective metabolite quantification. The results wil

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age: 18-65 years old 2. Body Mass Index (BMI): 18.5-29.9 kg/m2 3. Weight stability within the previous 3 months (self-reported). 4. Positive intention to maintain usual routine physical activity and eating habits during the study. Exclusion Criteria: 1. Presence of acute chronic diseases, inflammatory or functional gastrointestinal disorders, or any diagnosed disease condition that disrupt daily routine activities. 2. Routine use medications or supplements that could potentially interfere with the study outcomes 3. History of eating disorder 4. Recent use of antibiotic medication within the last 3 months prior to the first visit 5. Active efforts to lose weight 6. Smoking 7. Consumption of alcoholic drinks exceeding nine standard cups per week and/or more than three standard cups per occasion
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What it tests

  • Burger
  • Daily blood microsampling
  • Daily glucose monitoring
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Where

1 site
School of Medical Sciences
Örebro, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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