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Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid

RecruitingNAAges 18 Years - 89 YearsAllUniversity of Montana
NCT07531901 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy adults at least 18 years of age * Consent to audio/video recording of the research sessions for research purposes * Spirometry testing results obtained by study team on same day of first testing session with FEV1/FVC ratio and FEV1 percent predicted values of at least 0.70 Exclusion Criteria: * Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session) * Smoking of any substance in the last six months * Diagnosed or suspected pulmonary disease (e.g., asthma, COPD) * History of chronic cough * History of head or neck cancer * History of neurological disease (e.g., cerebrovascular accident) * History of dysphagia (swallowing difficulty) * Current complaint of a voice problem * Current upper respiratory infection
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What it tests

  • Cosmed QuarkSpiro Dosimeter-Controlled Nebulizer
  • DeVilbiss 45 Handheld Nebulizer
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Where

1 site
University of Montana
Missoula, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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