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SCN9A Gene Expression and Inflammatory Cytokines

Recruitingn/aAges 18 Years - 50 YearsAllJamia Millia Islamia
NCT07532200 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Voltage-gated sodium channels, especially Nav1.7 encoded by the SCN9A gene, are key regulators of nociceptive transmission. Upregulation of SCN9A has been associated with increased neuronal excitability and heightened pain perception. In parallel, inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-ฮฑ), and interleukin-1 beta (IL-1ฮฒ) are known to sensitize peripheral nociceptors and reduce the efficacy of local anesthetics by modifying tissue environment and ion channel activity. However, the combined influence of SCN9A expression and inflammatory cytokines on anesthetic success in SIP has not been fully elucidated. This prospective case-control study aims to evaluate the association between SCN9A gene expression and inflammatory cytokine levels with the clinical success of IANB in patients with SIP affecting mandibular molars. Approximately 90-100 patie

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18-60 years * Systemically healthy individuals (ASA I or II) * Presence of a mandibular first or second molar diagnosed with symptomatic irreversible pulpitis * Vital tooth confirmed by positive response to pulp sensibility tests (cold test/EPT) * Moderate to severe preoperative pain (Heft-Parker VAS) * Patients requiring endodontic treatment under inferior alveolar nerve block * Ability and willingness to provide informed consent Exclusion Criteria: * Patients who have taken analgesics, anti-inflammatory drugs, or antibiotics within the last 48 hours * Presence of systemic diseases affecting pain perception or inflammation (e.g., diabetes, neuropathic disorders) * Pregnant or lactating women * Teeth with periapical abscess, swelling, or sinus tract * Non-vital teeth or teeth with previous endodontic treatment * Patients with known allergy to local anesthetic agents * Patients with limited mouth opening or anatomical conditions affecting IANB administration * Inability to understand pain assessment scales or comply with study protocol
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What it tests

  • Inferior Alveolar Nerve Block
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Where

1 site
Faculty of Dentistry
New Delhi, India
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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