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NIMA-Colon Cancer Study

RecruitingNAAges 18 Years - 75 YearsAllFundación Pública Andaluza para la Investigación …
NCT07534852 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to evaluate the effects of nutritional supplementation and physical activity interventions on recovery, muscle strength, nutritional status, inflammation, and metabolic health in adults with colon cancer undergoing surgery. Patients with colon cancer frequently experience loss of muscle mass, reduced physical function, and nutritional deterioration both before and after surgery, which may adversely affect recovery and quality of life. A key objective of this study is to assess whether a postoperative intervention combining nutritional supplementation with beta-hydroxy beta-methylbutyrate (HMB) and vitamin D, together with a structured physical activity program, can improve muscle strength and functional recovery following colon cancer surgery. This study aims to answer the following questions: * Does nutritional supplementation with HMB and vitamin D, combin

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 to 75 years. * Male and female participants. * Diagnosis of colon cancer at localized or locally advanced stages (TNM stages I-III). * Patients scheduled for primary surgical treatment. Exclusion Criteria: * Metastatic disease (stage IV) * Diagnosis of rectal cancer or tumors involving the rectum * Prior neoadjuvant chemotherapy or radiotherapy before surgery. * Presence of synchronous malignant tumors. * Pregnant or breastfeeding women. * Presence of severe medical conditions, including acute pancreatitis, severe liver or kidney disease, heart failure, severe pulmonary disease, or peripheral arterial disease affecting the lower limbs. * Diagnosis of anorexia nervosa or other severe eating disorders. * Known allergy or intolerance to any nutritional supplements used in the study. * Medical contraindications to moderate-to-vigorous physical activity. * Regular participation in high-intensity exercise programs. * High risk of poor adherence to the study procedures, as determined by the study team.
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What it tests

  • Standard hypercaloric-hyperproteic nutritional supplementation
  • HMB-enriched hypercaloric-hyperproteic nutritional supplementation with vitamin D and calcium
  • Supervised exercise program
  • General physical activity recommendations
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Where

1 site
Hospital Universitario Virgen de la Victoria
Málaga, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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