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โ† Trials
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Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment

RecruitingNAAges 18 Years - 50 YearsFemaleNadezhda Women's Health Hospital
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In plain words

What the trial is, and whether it could suit you

The success rate after treatment by in-vitro fertilisation (IVF) strongly depends on the endometrial receptivity, which in turn is strictly connected to the endometrial immune profile. IVF outcome is largely dependent upon endometrial immune cell ratios and their relationship with one another. During the last few years there are several studies and case reports for intrauterine PRP application in patients resulting in a thicker, regenerated endometrium and better immune cell population ratios. In this project, the investigators aim to analyze the effect of autologous intrauterine PRP administration on the endometrial immune profile, endometrial thickness, selected hormone levels (E2, P4) during the mid-luteal phase and IVF outcomes (biochemical and clinical pregnancy).

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Participating in Assisted Reproduction Treatment * Having infertility * Having regular menstrual cycles * Embryo transfer of euploid embryos Exclusion Criteria: * Uterine pathologies * Endometrial Bacterial infections * Active endometrial inflammation * Polycystic ovary syndrome * Cancer diagnostics * Positive HIV, HCV or HBV tests * Autoimmune diseases * Recent immune therapy
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What it tests

  • Platelet rich plasma (PRP)
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Where

1 site
Nadezhda Women's Health Hospital
Sofia, Bulgaria
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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