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Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness

RecruitingPhase 2, Phase 3Ages 18 Years - 80 YearsAllXijing Hospital
NCT07535593 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy. To date, limited evidences support the use of amantadine and transcranial direct current stimulation in this population. Bloodletting puncture (BP) at the hand twelve Jing-Well points (HTWPs) has been traditionally used in China as an empirical therapy for DoC; however, its efficacy has not been established by robust clinical evidence. Transcutaneous electrical acupoint stimulation (TEAS) provides a modern, noninvasive alternative for acupoint stimulation. The Wells-DoC trial, a multicenter, randomized, controlled, open-label study with blinded endpoint assessment, provided preliminary evidence that TEAS applied at the hand twelve Jing-Well points was associated with a numerically higher proportion of consciousness improvement in patients with DoC, al

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age: 18-80 years old; * From 7 to 90 days since brain injury; * Diagnosed in VS/UWS or MCS as defined by at least two CRS-R assessments performed during the screening period * Acquired cerebral damage of known etiology * Intact hand skin * Informed consent given by the legal surrogate Exclusion Criteria: * Patients who continuously receive sedative drugs and Na+ or Ca2+ channel blockers (e.g., carbamazepine) or NMDA receptor antagonists (e.g., dextromethorphan) * History of previous serious、progressive neurological disorder prior to the brain injury; * Epilepsy and seizure * Unstable vital signs or life-threatening comorbidities * Implanted devices: including cardiac pacemakers or implantable cardioverter-defibrillators (ICDs), deep brain stimulators, ventriculoperitoneal (VP) shunts, and other indwelling electronic or neurosurgical implants. * Documented pregnancy
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What it tests

  • Transcutaneous electrical stimulation
  • Sham electrical stimulation
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Where

1 site
Xijing Hospital
Xi'an, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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