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โ† Trials
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Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients

Recruitingn/aAges 18 Years - anyAllCHU de Reims
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In plain words

What the trial is, and whether it could suit you

Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status, challenging the concept of a linear continuum between preload independence and fluid intolerance. These findings support the need for a more individualized hemodynamic management strategy that takes venous congestion risk into account. The right ventricle plays a central role in this framework. Its function is to maintain an adequate venous return pressure gradient to ensure cardiac output while limiting upstream venous congestion, under strong dependence on its afterload. In physiological conditions, the right ventricle adapts to changes in afterload by increasing contractility to preserve right ventriculo-arterial coupling and optimize its performance. In chronic

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria: * Critically ill hospitalized patients * Age โ‰ฅ 18 years * Patients undergoing fluid loading at the discretion of the attending physician, following prediction of fluid responsiveness using any recommended maneuver or dynamic parameter, in the setting of acute circulatory failure requiring vasopressor support and/or mean arterial pressure \< 65 mmHg (or a decrease of โ‰ฅ 30 mmHg from baseline in patients with chronic hypertension), and/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia) * Affiliated with a national health insurance system Exclusion criteria : * Formal refusal from the patient or legally representative after information * Patients transferred from another intensive care unit * Pregnant or postpartum patients * Acute respiratory distress (defined as respiratory rate โ‰ฅ 35 breaths/min and/or signs of increased work of breathing) * Ongoing acute coronary syndrome * Acute or pulmonale (defined by right ventricular dilation associated with paradoxical septal motion related to an abrupt increase in right ventricular afterload) * Primary pulmonary arterial hypertension * Intra-abdominal hypertension (intravesical pressure \> 15 mmHg) * Poor echogenicity precluding adequate echocardiographic assessment of the right ventricle * Severe valvular heart disease or early postoperative period following valvular surgery
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What it tests

  • Echography
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Where

1 site
Marie Muller
Reims, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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