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Cervical Spinal Cord Associative Plasticity

RecruitingNAAges 18 Years - 80 YearsAllColumbia University
NCT07539025 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the cervical spinal cord induce significantly larger upper limb motor responses than if timed to converge in the motor cortex. The goal of this prospective experimental study in typically developing adults is to test the effects of pairing sub-threshold hand motor cortical and median nerve stimulation targeted to induce plasticity in the cervical spinal cord, rather than in the motor cortex. Based on preliminary data, the investigators are performing a confirmatory study to test the physiological and behavioral effects of the paired brain and peripheral nerve protocol, called the SCAP-Nerve protocol. This study will first be conducted in typically developing adults to co

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📋 Eligibility rules (as published)
Inclusion Criteria: * Willingness to participate in up to 4 sessions * Maintenance of caffeine and exercise levels at time of sessions * Ability to provide informed consent * No known central or peripheral neurological disease or injury * No known musculoskeletal injury of the tested arm or hand Exclusion Criteria: * Personal or family history of seizures * Use of medications that lower seizure threshold * History of implanted equipment including stimulators/pacemakers
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What it tests

  • SCAP
  • MagPro X100
  • Digitimer DS8R
  • Paired non-associative stimulation
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Where

1 site
Columbia University Irving Medical Center
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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