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โ† Trials
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A Phase 1 Study of Navlimetostat Tablet Formulations

RecruitingPhase 1Ages 18 Years - 55 YearsFemaleBristol-Myers Squibb
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In plain words

What the trial is, and whether it could suit you

This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Participants must be healthy adult INOCBP female with no clinically significant findings on medical history, PE, VS, 12-lead ECGs, or clinical laboratory determinations, as assessed by the investigator. * Participants must have BMI of 18.0 to 35.0 kg/m2. * Participants must have adequate laboratory test results for renal and hepatic function, as assessed by the investigator, defined as eGFR โ‰ฅ 90 mL/min/1.73m2 using the CKD-EPI equation (screening only), and total bilirubin, ALP, GGT, AST, ALT โ‰ค 1.5 ร— ULN. Exclusion Criteria: * Participant must not have any significant acute or chronic medical illness (in the assessment of the investigator). * Participant must not have current or recent GI disease: Any gastrointestinal disease within 3 months of study intervention administration that could possibly affect drug absorption, distribution, metabolism, and excretion (eg, bariatric procedure, history of pancreatitis, uncontrolled nausea or vomiting) in the opinion of the investigator. * Other protocol defined inclusion/exclusion criteria applies.
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What it tests

  • Navlimetostat
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Where

4 sites
CenExel iResearch - Decatur
Decatur, United States
Local Institution - 0003
Decatur, United States
Local Institution - 0001
Austin, United States
Local Institution - 0004
Austin, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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