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Screening for Biomarkers of Osteonecrosis of the Femoral Head

Recruitingn/aAges 18 Years - 70 YearsAllThe First Affiliated Hospital of Xinxiang Medical…
NCT07545616 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and economic burden on patients. Early intervention can significantly improve the long-term prognosis of ONFH. However, due to the lack of validated biomarkers for early diagnosis, the early diagnostic rate remains low, with a primary diagnostic rate of merely 68.43% at the first visit, accompanied by a high rate of misdiagnosis. This project intends to collect blood samples from patients diagnosed with ONFH and suspected cases in the orthopedic outpatient department of a tertiary Grade A hospital. Diagnostic and differential diagnostic tests will be adopted to evaluate the clinical application value of previously reported candidate biomarkers, so as to screen out biom

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Aged between 18 and 70 years old (inclusive). 2. Patients with suspected ONFH. 3. Those who provide informed consent and volunteer to participate in this study. Exclusion Criteria: 1. Patients with a clear history of hip trauma. 2. Patients with ONFH secondary to traumatic factors such as femoral neck fracture and hip dislocation. 3. Patients complicated with severe mental illness or cognitive impairment who are unable to cooperate with questionnaire completion. 4. Patients who refuse to sign the informed consent form.
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What it tests

  • Not listed
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Where

1 site
The First Affiliated Hospiatl of Henan Medical University
Xinxiang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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