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โ† Trials
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Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

RecruitingNAAges 60 Years - 75 YearsAllUniversity of Alabama at Birmingham
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In plain words

What the trial is, and whether it could suit you

Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with normal blood sugar levels. The study will also test whether a single dose of an exogenous ketone supplement can improve brain energy use and cognitive processing speed. The main questions it aims to answer are: Do older adults with prediabetes have lower brain glucose uptake and slower cognitive processing speed compared to those with normal glucose levels? Does a single dose of an exogenous ketone monoester supplement improve cognitive processing speed and brain glucose uptake? Researchers will compare older adults with prediabetes to older adults with normal glucose levels to determine whether differences exist in brain glucose metabolism and cognitive performa

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 60 to 75 years * Able to provide written informed consent * Fluent in English * No diagnosed cognitive impairment or dementia Classified as either: * Prediabetes (based on American Diabetes Association criteria), or Normal glucose regulation (control group) * Medically stable and cleared to undergo positron emission tomography and magnetic resonance imaging * Willing to comply with study procedures, including metabolic testing, supplement ingestion, and neuroimaging Exclusion Criteria: * Diagnosis of mild cognitive impairment, dementia, or other neurodegenerative disorder * Diagnosis of type 1 diabetes or type 2 diabetes * Use of glucose-lowering medications (e.g., insulin, metformin, glucagon-like peptide-1 receptor agonists) * History of major neurological disorder (e.g., stroke, traumatic brain injury with loss of consciousness \>30 minutes, epilepsy, multiple sclerosis) * Major psychiatric disorder not stable on treatment * Uncontrolled hypertension or significant cardiovascular disease * Severe renal, hepatic, or gastrointestinal disease that may affect supplement metabolism * Contraindications to magnetic resonance imaging (e.g., non-compatible implanted devices, severe claustrophobia)
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What it tests

  • Ketone Monoester (KE)
  • Placebo
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Where

2 sites
UAB Comprehensive Cancer Center
Birmingham, United States
Webb Nutrition Sciences Building
Birmingham, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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