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Serum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal Bevacizumab

Recruitingn/aAges 50 Years - 80 YearsAllAtaturk University
NCT07550777 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Bevacizumab, an anti-VEGF (vascular endothelial growth factor) agent used in the treatment of diabetic retinopathy and macular edema associated with retinal vein occlusion, is commonly administered in ophthalmology clinics through intravitreal injection. The systemic use of bevacizumab has been associated with serious conditions such as thromboembolism and bleeding. Although intravitreal bevacizumab is administered in smaller amounts and has limited systemic circulation, it requires repeated injections over a long period. These long-term intravitreal anti-VEGF therapies may lead to adverse outcomes, particularly thromboembolism, due to systemic inhibition of VEGF. However, limited information is available regarding the potential effects of this treatment on the systemic and cardiovascular systems. To evaluate this risk, the study aims to assess changes in the activities of paraoxonase 1

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 55 years. * Ability to provide written informed consent. * Patient group: Diagnosis of macular edema secondary to diabetic retinopathy, retinal vein occlusion, or age-related macular degeneration, and having received repeated intravitreal bevacizumab injections (≥2 doses). * Control group: Healthy volunteers with no ocular pathology other than cataracts and not receiving intravitreal anti-VEGF treatment. Exclusion Criteria: * Chronic inflammatory disease. * Chronic infectious disease. * History of cardiovascular disease (e.g., coronary artery disease, heart failure, arrhythmia requiring treatment). * History of cerebrovascular disease (e.g., stroke, transient ischemic attack). * Any additional ocular pathology that may affect the study outcomes (other than the index retinal condition in the patient group and cataract in the control group), such as: glaucoma uveitis retinal dystrophies significant media opacity preventing adequate ocular evaluation \- Use of systemic medications or conditions known to affect cholinesterase activity markedly
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What it tests

  • blood test
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Where

1 site
Ataturk University Research Hospital, Department of Ophthalmology
Erzurum, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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