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โ† Trials
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Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

RecruitingPhase 3Ages 18 Years - anyAllHoffmann-La Roche
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of care (SOC) in participants with multiple myeloma (MM) who have received one to three prior lines of therapy and have been exposed to an anti-CD38 monoclonal antibody (mAb) and lenalidomide.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 at screening and immediately prior to start of administration of study treatment. * Individuals with ECOG Performance Status of 2 solely due to local symptoms of myeloma (e.g., pain) are eligible * MM diagnosis according to the International Myeloma Working Group (IMWG) diagnostic criteria * Received one to three lines of prior therapy that included at least two consecutive cycles of either of the following: A regimen containing an anti-CD38 therapy, a regimen containing lenalidomide * Participants must have measurable disease during screening Exclusion Criteria: * Known history of amyloidosis (e.g., positive Congo Red stain or equivalent in tissue biopsy or documented within serum amyloid P component scan) * Plasma cell leukemia or circulating plasma cell count exceeding 500 cells/liter (L) or 5% of the peripheral blood white cells * GI disease that might significantly alter absorption of oral drugs * Participants must not have any ongoing CNS disease or non-secretory myeloma
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What it tests

  • Cevostamab
  • Pomalidomide
  • Dexamethasone
  • Daratumumab
  • Elotuzumab
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Where

93 sites
City of Hope National Medical Center
Duarte, United States
City of Hope - Lennar Foundation Cancer Center
Irvine, United States
Yale University
New Haven, United States
MedStar Washington Hospital Center MedStar Georgetown Cancer Institute
Washington D.C., United States
Emory University Hospital Midtown
Atlanta, United States
Novant Health Cancer Institute
Charlotte, United States
Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists
Winston-Salem, United States
TriHealth Cancer and Blood Institute
Cincinnati, United States

โ€ฆand 85 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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