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The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

RecruitingPhase 4Ages 18 Years - anyAllBassett Healthcare
NCT07556107 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. Both combinations are approved by the Food and Drug Administration (FDA). The goal is to help doctors know which combination is safer so they can make better choices for their patients.

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📋 Eligibility rules (as published)
Inclusion criteria 1. Hospitalized or being hospitalized. 2. Age \>/=18 yr old. 3. Serious or suspected serious infection for which VPT or VM considered a broad-spectrum combination antibiotic backbone standard of care by clinician. 4. Enrollment can be completed before the first dose of abx (ideally) and no later than before the second dose (alternatively). 5. Consenting/enrollment will not clinically significantly delay abx administration. 6. Baseline and \>/=1 prior Scr available (within 1 yr). 7. Pt or LAR able to provide IC. Exclusion criteria 1\. AKI (\>/=moderate) (KDIGO stage 2-3) (Scr increase \>/=2-fold from chronic BL) (Scr based). 2\. CKD (\>/=moderately to severely decreased eGFR) (KDIGO stage G3b-G5) (by history or eGFR \</=44 mL/min/1.73M2) (Scr based). 3\. Beta lactam allergy. 4. Contraindication to VPT or VM. 5. Infection requiring VPT or VM specifically or another abx regimen. 6. Participation in another research study with interventions that may impact study endpoints.
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What it tests

  • Piperacillin + Tazobactam
  • meropenem
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Where

7 sites
University of Massachusetts Chan Medical School
Worcester, United States
University of Nebraska Medical Center
Omaha, United States
Bassett Medical Center
Cooperstown, United States
NY Presbyterian/Queens
Flushing, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Medical University of South Carolina - South Carolina Clinical & Translational Research Institute
Charleston, United States
West Virginia University
Morgantown, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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