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Effect of Apiban Therapy on AVF Maturation in ESRD Patients

RecruitingNAAges 18 Years - anyAllCombined military hospital lahore
NCT07559942 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

End-stage renal disease (ESRD) is a growing global health burden, and the creation of a native arteriovenous fistula (AVF) is the gold standard for vascular access in patients requiring hemodialysis \[1\]. AVFs offer superior longevity, fewer infectious complications, and lower mortality rates compared to central venous catheters or synthetic grafts \[2\]. However, a significant limitation to their widespread success is the high rate of early failure, primarily due to failure to mature (FTM). FTM occurs in 20-40% of AVFs, rendering them unusable for dialysis \[3\]. Apixaban, a direct factor Xa inhibitor, offers a potential advantage by providing sustained anticoagulation throughout the critical maturation period \[7\]. Its predictable pharmacokinetics, oral administration, and favorable safety profile make it an attractive agent for short-term use in this setting \[8\]. By reducing micr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years. * Diagnosis of ESRD (eGFR \< 15 mL/min/1.73m² or already on dialysis) with plans for hemodialysis. * Planned primary upper extremity AVF creation (radiocephalic, brachiocephalic, or brachiobasilic). * Suitable vessels on preoperative duplex ultrasound (artery ≥ 2 mm, vein ≥ 2.5 mm without tourniquet). * Ability to provide informed consent. Exclusion Criteria: * Known bleeding diathesis or hypercoagulable state. * Current therapeutic anticoagulation (any indication). * Current dual antiplatelet therapy. * History of intracranial hemorrhage. * Known allergy or hypersensitivity to apixaban. * Inability to comply with study protocol or follow-up.
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What it tests

  • Apixaban
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Where

1 site
Combined Military Hospital, Lahore
Lahore, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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