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Adaptive Recruitment Curve Analysis Using Bayesian Modeling

RecruitingNAAges 18 Years - 90 YearsAllColumbia University
NCT07561372 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to better understand how electrical or magnetic stimulation affect the nervous system by optimizing the way researchers measure muscle responses. The relationship between stimulation intensity and muscle response is described by "neural recruitment curves," which are critical for monitoring the state of the nervous system during therapies like transcranial magnetic stimulation (TMS) and spinal cord stimulation (SCS). This study tests a new, real-time computational approach based on our previously developed methods (Hierarchical Bayesian models) to estimate these recruitment curves more efficiently. The primary goal is to use this model to dynamically guide the experiment, automatically selecting the optimal stimulation intensities to test. The investigators hypothesize that this optimized approach will accurately estimate the entire recruitment curve, or sp

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy adult volunteers aged 18 years and older. * Able to understand study procedures and provide written informed consent. Exclusion Criteria: * 1\. History of adverse reaction to Transcranial Magnetic Stimulation (TMS) or non-invasive neurostimulation. * 2\. History of seizures, epilepsy, or family history of epilepsy. * 3\. History of stroke, brain injury, or illness causing brain injury. * 4\. History of head injury or neurosurgery. * 5\. History of neurological diseases, or central nervous system lesions. * 6\. Presence of metallic implants or foreign bodies in the head (outside of dental work/fillings). * 7\. Presence of implanted electronic or medical devices (e.g., cardiac pacemakers, medical pumps, implanted stimulators). * 8\. Current pregnancy or possibility of pregnancy. * 9\. Currently taking medications that alter cortical excitability or lower seizure threshold.
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What it tests

  • Algorithm: Uniform Sampling
  • Algorithm: hbMEP-adaptive algorithm (version 1)
  • Algorithm: hbMEP-adaptive algorithm (version 2)
  • ML-PEST
  • MagPro X100 Transcranial Magnetic Stimulation
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Where

1 site
Columbia University Irving Medical Center
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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