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Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder

RecruitingNAAges 18 Years - 65 YearsAllIstanbul University - Cerrahpasa
NCT07561528 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Purpose: This study aims to evaluate the effectiveness of an accelerated intermittent Theta Burst Stimulation (iTBS) protocol-a non-invasive brain stimulation technique-targeted at the dorsomedial prefrontal cortex (dmPFC) and anterior cingulate cortex (ACC) in patients with treatment-resistant Obsessive-Compulsive Disorder (OCD). Additionally, the study seeks to identify electrophysiological biomarkers (such as EEG microstates and heart rate variability) that may predict which patients are most likely to benefit from the treatment. Methodology: The study will include 30 patients aged 18-65 diagnosed with OCD according to DSM-5 criteria who have not responded sufficiently to standard treatments. Participants will undergo an intensive 7-day treatment program consisting of 4 iTBS sessions per day (totaling 28 sessions). Clinical symptoms will be assessed before and after the treatment u

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📋 Eligibility rules (as published)
Inclusion Criteria: * Being between 18 and 65 years of age. * Being diagnosed with Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria. * Non-responsiveness to at least one Selective Serotonin Reuptake Inhibitor (SSRI) treatment at an adequate dose and duration. * Having a Y-BOCS score of ≥20 following the initial evaluation. * No change in the current medications within the last 2 months and a commitment to maintaining stable doses throughout the study. * Providing informed consent and having no contraindications for TMS. Exclusion Criteria: * Severe neurological disorders or neurodegenerative diseases. * Any condition associated with increased seizure risk * History of cochlear implants, metal implants in the head and neck area, cardiac pacemakers, deep brain stimulation, or vagus nerve stimulation. * History of neurosurgical intervention. * General contraindications for Transcranial Magnetic Stimulation therapy.
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What it tests

  • iTBS TMS
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Where

1 site
Cerrahpaşa Tıp Fakültesi Prof. Dr. Murat Dilmener Hastanesi
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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