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Exercise Training After Upper Gastrointestinal Cancer Surgery

RecruitingNAAges 18 Years - anyAllKansai Medical University
NCT07561840 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled trial aims to determine the optimal exercise intensity for improving postoperative recovery in patients with upper gastrointestinal cancer. Participants who have undergone curative surgery will be randomly assigned to high-intensity interval training (HIIT), low-intensity continuous training (LICT), or usual care. The exercise interventions will be performed under supervision three times per week for eight weeks. The primary outcome is peak oxygen uptake (VO₂peak), assessed using cardiopulmonary exercise testing. Secondary outcomes include physical function, body composition, patient-reported outcomes, and biological and mechanistic markers such as inflammatory biomarkers, muscle-related factors, and gut microbiota. This study will also explore potential mechanisms underlying exercise-induced adaptations and their association with clinical outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Diagnosed with esophageal or gastric cancer * Received curative surgery * 6 ± 2 weeks after surgery * Ability to provide written informed consent Exclusion Criteria: * Communication difficulties * Poor general status * Undergone combined laryngopharyngectomy * Unsuitable for evaluation or exercise intervention * Unsuitable for the study as determined by the primary physician
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What it tests

  • High-Intensity Interval Training (HIIT)
  • Low-Intensity Continuous Training (LICT)
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Where

2 sites
Kansai Medical University
Hirakata, Japan
Kansai Medical University
Hirakata, Japan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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