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COmparison of Maintenance of Propofol And Sevoflurane Spectral Study

RecruitingNAAges 18 Years - anyAllCliniques universitaires Saint-Luc- Université Ca…
NCT07561970 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lower EEG alpha band power is currently extensively studied as a potential biomarker of brain vulnerability. No previous study has evaluated whether there was a difference in EEG power spectrum ranges between propofol and sevoflurane, the two main anesthetic agents for maintenance of general anesthesia, in order to define a cut-off value for the prediction of a higher risk of postoperative delirium. * Primary objective: comparison of EEG alpha power (dB) during maintenance of anesthesia with propofol and sevoflurane using data available in the NeuroSense® depth-of-anesthesia monitoring * Secondary objectives: comparison of other EEG frequency bands during maintenance of anesthesia with propofol and sevoflurane using data from the NeuroSense® depth-of-anesthesia monitoring

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📋 Eligibility rules (as published)
Inclusion Criteria: Adult patients undergoing elective electrophysiological interventions, such as atrial fibrillation ablation procedures, under general anesthesia * Capable to give informed consent * French-speaking patients Exclusion Criteria: * Need for a premedication with benzodiazepine before anesthesia * Reduced left ventricular ejection fraction (\< 50%) or underlying cardiac pathology requiring a more balanced anesthesia (administration of benzodiazepine and/or ketamine during anesthesia) * Preoperative MoCA score \< 26/30 (for patients \> ou = 55 years old) * Patients treated with anti-epileptic drugs * Patients treated with benzodiazepines (ex: for anxiolysis or sleep disorders) * Emergencies * Morbid obesity (BMI \> 40kg/m2) * Background of severe postoperative nausea/vomit
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What it tests

  • Maintenance of general anesthesia by Propofol
  • Maintenance of general anesthesia by Sevoflurane
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Where

1 site
Cliniques universitaires Saint-Luc
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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