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โ† Trials
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Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg

RecruitingNAAges 18 Years - 71 YearsAllAin Shams University
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In plain words

What the trial is, and whether it could suit you

Ureteral stenting is a common urological procedure performed to relieve obstruction and facilitate urinary drainage. Despite its effectiveness, stent-related symptoms (SRS) such as dysuria, frequency, urgency, flank pain, and sexual discomfort negatively affect patient quality of life. Pharmacological management with alpha-blockers such as Tamsulosin and phosphodiesterase-5 inhibitors (PDE5i) such as Tadalafil has shown promise in reducing SRS. While low-dose Tadalafil (2.5 mg) has not been explored, its comparative effectiveness against the standard 5 mg dose when combined with Tamsulosin remains under-researched. This study aims to evaluate the difference in reduction of SRS between Tamsulosin with Tadalafil in standard and half dosage.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: \- patients older than 18 years of age, with presence of a double-J (DJ) stent (polyurethane) post endoscopic stone removal. Exclusion Criteria: * Patients younger than 18 years of age were excluded. * Patients with a history of prostate or bladder surgery were excluded. * Patients with prior lower urinary tract procedures were excluded. * Patients with cancer were excluded. * Patients with neurological conditions were excluded. * Patients with a history of pelvic radiation were excluded. * Patients with diabetes were excluded. * Patients with kidney dysfunction (acute or chronic) were excluded. * Patients with a solitary kidney were excluded. * Patients with congenital urinary anomalies were excluded. * Patients taking the following medications were excluded: * ฮฑ-blockers * beta-blockers * calcium channel blockers * 5-alpha reductase inhibitors * PDE5 inhibitors * anticholinergics * nitrates * Patients with cardiac issues were excluded. * Patients with residual stone fragments after surgery were excluded. * Patients with multiple or bilateral ureteral stones were excluded. * Patients with long-term or bilateral stents requiring frequent changes were excluded. * Patients with interstitial cystitis were excluded. * Patients with chronic cystitis were excluded. * Patients with prostatitis were excluded. * Pregnant women were excluded. * Breastfeeding women were excluded. * Patients unavailable for follow-up were excluded.
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What it tests

  • Tamsulosin
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Where

1 site
Ain Shams University Hospital
Cairo, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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