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Exercise Intensity and Muscle Recovery in Statin Users

RecruitingNAAges 30 Years - 65 YearsAllRaffaele Mazzolari
NCT07563452 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate how different types and intensities of exercise affect muscle recovery in individuals taking statin medications compared to healthy controls. Statins are essential for cardiovascular prevention but are often associated with muscle-related side effects (SAMS), which can be exacerbated by physical activity. The study will compare aerobic cycling (low muscular strain) with resistance training (RT) at increasing intensities (40%, 60%, and 80% of estimated 1-repetition maximum; e1RM). Researchers will measure markers of muscle damage, such as creatine kinase (CK) levels, and subjective recovery needs to determine which exercise modalities and intensities are best tolerated by statin users. The goal is to provide evidence for more individualized and safer exercise recommendations for this population.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sedentary behavior (defined as \< 1 hour of planned physical activity per week) * Low occupational physical activity * Age between 30 and 65 years * Non-smoker * Medical clearance to partake in physical exercise (as determined during screening visit) * For statin users: Current statin medication with stable dosage for at least 8 weeks prior to enrollment * For controls: Statin-naïve individuals Exclusion Criteria: * BMI \< 20 kg/m² or \> 30 kg/m² * Smoking or smoking cessation \< 1 year ago * Medical conditions or musculoskeletal issues that preclude eligibility for full physical effort or interfere with outcome measures * Medication (other than statins) that may interfere with physical exercise or outcome measures (assessment on a case-by-case basis during screening visit) * Any condition identified during screening (e.g., abnormal ECG, cardiopulmonary exercise test) that, in the opinion of the physician, precludes safe participation
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What it tests

  • Dose-Escalation Exercise Protocol
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Where

1 site
University of Innsbruck
Innsbruck, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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