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FAPI PET/CT Imaging in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (FAPI-ARVC))

RecruitingNAAges 18 Years - anyAllIstanbul University - Cerrahpasa
NCT07563660 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease associated with fibrofatty myocardial replacement, ventricular arrhythmias, and an increased risk of sudden cardiac death. Although current diagnostic approaches, including the 2010 Task Force Criteria and the Padua criteria, improve recognition of the disease, early diagnosis remains challenging, particularly when structural abnormalities are subtle or absent on conventional imaging. Echocardiography and cardiac magnetic resonance imaging are central to evaluation, but their sensitivity for early or active fibrotic remodeling may be limited. This limitation may be particularly relevant in patients who are unable to undergo cardiac magnetic resonance imaging, in whom 68Ga-DOTA-SA-FAPI PET/CT may provide complementary diagnostic information. This prospective single-group diagnostic imaging study a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 years or older * Established diagnosis of arrhythmogenic right ventricular cardiomyopathy according to the 2010 Revised Task Force Criteria and/or the Padua criteria * Under active follow-up at the study center * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * History of malignancy * Severe renal impairment * Severe hepatic impairment * Pregnancy or breastfeeding * Prior 68Ga-DOTA-SA-FAPI PET/CT imaging * Inability or unwillingness to provide written informed consent * Any medical, clinical, or logistical condition that, in the opinion of the investigators, could interfere with study participation, image interpretation, or completion of follow-up
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What it tests

  • 68Ga-DOTA-SA-FAPI PET/CT
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Where

1 site
Istanbul University-Cerrahpasa Institute of Cardiology
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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