๐ฌIn plain words
What the trial is, and whether it could suit you
This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.
Sign in to get the eligibility rules as simple questions to take to your doctor.
๐ Eligibility rules (as published)
Inclusion Criteria:
* Aged 21 years or older
* Currently smoke cigarettes daily (โฅ 5 cigarettes/day) for at least the past 6 months, and their usual brand is menthol cigarettes
* Willing to provide informed consent
* Willing to abstain from all nicotine, tobacco, and smoked cannabis products for approximately 12 hours prior to each study visit
* Own and regularly use a functional smartphone compatible with study procedures (e.g., completing daily assessments)
* Willing to complete two weeks of daily assessments involving use of their usual brand menthol cigarettes and the study product
* Able to read, speak, and understand English
Exclusion Criteria:
* Current diagnosis of any significant lung diseases (e.g., asthma, chronic obstructive pulmonary disease, cystic fibrosis)
* History of a cardiac event or episode of cardiac distress (e.g., heart attack, hospitalization for chest pain) within the past 3 months
* Currently pregnant, planning to become pregnant during the study period, or currently breastfeeding
* Self-reported use of any non-cigarette nicotine or tobacco product (e.g., e-cigarettes, cigars, oral nicotine products) or cannabis on more than 10 days in the past 30 days
* Self-reported current participation in a smoking cessation program or intention to quit smoking in the next 3 months
* Self-reported difficulty with blood draws
๐
What it tests
- Biospecimen Collection
- Questionnaire Administration
- Cigarette Purchase Task
- Cross-Price Elasticity Task
- Daily Diary Surveys
Ohio State University Comprehensive Cancer Center
Columbus, United States
๐ค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ always decide together with your own doctor.