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Local Hyperthermia Combined With Topical 3% Hydrogen Peroxide for Refractory Viral Warts

RecruitingNAAges any - anyAllFirst Hospital of China Medical University
NCT07565350 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. Background of the Problem Viral warts result from infection of the skin or mucous membranes by human papillomavirus (HPV). Some patients develop refractory cases due to abnormal immune function, persistent viral presence, or recurrent warts. The clinical challenge in treating refractory viral warts lies in the limited effectiveness of single therapeutic approaches, high recurrence rates, and the fact that a significant proportion of patients are infected with high-risk or special HPV subtypes. These factors necessitate combined multi-modal treatments and genetic etiological screening. 2. Current Treatment Status Thermotherapy (44°C ± 2°C, 30 minutes per session): Studies have demonstrated that it can stimulate the activation of local immune cells (such as Langerhans cells), thereby enhancing antiviral immune responses. Hydrogen peroxide: It possesses antibacterial properties and p

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📋 Eligibility rules (as published)
Inclusion Criteria: \- 1: Patients with a disease course of ≥2 years who have failed to respond to ≥2 treatment methods (such as topical ointments, cryotherapy, laser therapy, etc.) 2: The subject or their legal guardian is able to understand and sign the informed consent form/agree to participate in the study. Exclusion Criteria: * 1: The subject or their legal guardian is unable to understand and refuses to sign the informed consent form / refuses to participate in the study 2: Individuals allergic to local hyperthermia or hydrogen peroxide; 3: Subjects with tumors or other serious diseases are unable to complete this clinical study; 4: Due to personal or other objective reasons, it is not possible to ensure timely treatment and follow-up.
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What it tests

  • An infrared hyperthermia device
  • Hydrogen Peroxide 3 % Topical Solution
  • Normal Saline (NS)
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Where

2 sites
Infrared hyperthermia device (Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China)
Shenyang, China
Infrared hyperthermia device (Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China)
Shenyang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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