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Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy

RecruitingNAAges 18 Years - 65 YearsAllXuanwu Hospital, Beijing
NCT07566663 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

This study will determine the optimal timing for Anrikefon administration. It will also assess the quality of patient recovery. Laparoscopic cholecystectomy (LC) is a routine surgical procedure. However, the incidence of acute visceral and incision pain is high, reaching 50% to 70%. This pain significantly impairs patient recovery. Anrikefon is novel peripherally restricted ฮบ-opioid receptor agonist. It has very low brain penetration. This property reduces central nervous system side effects and respiratory depression. Preventive analgesia blocks the transmission of nociceptive stimuli to the central nervous system. It reduces postoperative pain sensitization and intensity. Currently, research on Anrikefon for preventive analgesia in LC patients is limited. It impacts on the recovery process is not yet fully understood. This study will compare drug administration before anesthesia induc

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. ASA physical status classification I-III; 2. Age 18-65 years; 3. Scheduled for elective laparoscopic cholecystectomy; 4. Voluntary signed informed consent; 5. BMI between 18-28 kg/mยฒ; 6. No history of general anesthesia surgery within the past 3 months. Exclusion Criteria: 1. Severe cardiovascular disease, respiratory disease, or psychiatric disorders; 2. Severe renal insufficiency; 3. Recent use of diuretics or compound medications containing diuretics; 4. Continuous use of opioid analgesics for more than 10 days within the past 3 months; 5. Use of medications with unknown half-life affecting analgesic efficacy within 14 days prior to randomization; 6. Pregnant women, lactating women, or those planning pregnancy in the near future; 7. History of hypersensitivity to study medications.
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What it tests

  • Anrikefon for Preventive Analgesia
  • Anrikefon for bridging analgesia
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Where

1 site
Xuanwu Hospital, Capital Medical University
Beijing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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