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Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study

Recruitingn/aAges 18 Years - 65 YearsAllBozok University
NCT07567300 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity. In addition to headaches, other musculoskeletal pains are also frequently reported in migraine patients. Spinal p

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📋 Eligibility rules (as published)
Inclusion Criteria: * Being between 18 and 65 years of age, * Being able to read and understand Turkish, * Agreeing to participate voluntarily, * Having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria; * Having neck pain and/or lower back pain without any underlying diagnosis accompanying the migraine diagnosis. Exclusion Criteria: * A history of neurological disorder (e.g., Multiple Sclerosis), * Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis), generalized chronic pain syndromes (e.g., Fibromyalgia), * Any other headache disease, any other systemic disease, * Acute fracture and infection, * Spinal surgery or spinal disease diagnosis within the last 6 months, * Serious musculoskeletal trauma within the last 6 months, * Pregnancy, * A cognitive or psychiatric condition that would prevent completion of the questionnaires, * In the control group without a migraine diagnosis, * A history of recurrent headaches within the last year.
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What it tests

  • Not listed
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Where

1 site
Gazi University
Gaziantep, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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