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Tolerance to an Artisanal Bread in a Population Intolerant of the Conventional Bread and Study of Associated Markers

RecruitingNAAges 18 Years - 65 YearsAllInstitut National de Recherche pour l'Agriculture…
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In plain words

What the trial is, and whether it could suit you

The objective of this study is to evaluate the effect of consuming an "artisanal" bread for 15 days on gastrointestinal symptoms in individuals intolerant to "conventional" bread. "Conventional bread" refers to bread made with refined wheat flour (ash = 0.55% of dry matter), containing gluten, and leavened with baker's yeast (Saccharomyces cerevisiae). "Artisanal bread" refers to bread made with whole wheat flour (ash = 1.50% of dry matter) from an ancient durum wheat variety (Russello) and leavened with sourdough.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Normal weight (18 \< BMI \< 25 kg.m-2) * Male or female * 18 to 65 years old * Adults reporting intolerance to "conventional" bread * Absence of celiac disease * Affiliated to a social security scheme * Free, informed and express consent Exclusion Criteria: * People under protective supervision: legal guardianship, tutorship or curatorship * People with eating disorders (anorexia, bulimia, binge eating) * Any known food allergy * Women who are pregnant or potentially pregnant (based on a positive urine pregnancy test at inclusion) * Breastfeeding women * Alcohol abuse (\>2 drinks/day). At the time of inclusion, the investigator will assess whether the participant exhibits harmful alcohol consumption * Untreated hypertension, uncontrolled diabetes, or diseases of the digestive tract (excluding functional intestinal disorders), liver, kidneys, or severe heart disease. The investigator will assess the presence of these conditions on standard clinical criteria and the participants' self-reported medical history at the time of inclusion * Participation in a clinical study in the three months preceding the study * Absence of express consent
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What it tests

  • Artisanal Bread
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Where

2 sites
Centre de Recherche sur Volontaires
Bobigny, France
Centre de Recherche sur Volontaires (CRV)
Bobigny, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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